Reader cannot prevent a user from Force Quitting on a Mac nor Control-Alt-Delete on a PC. So perhaps you would be best off with a an IPad or Android tablet with Reader installed. Have access to all buttons in the tablet removed by a locked enclosure. I am pretty sure that using enterprise administrative tools you can lookout most other programs on an iPad maybe able to use something similar on an Android or Windows RT Tablet. That would be the cheapest way to go.
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